[3] A very important function of vitamin D is to enhance the conversion of the amino acid tryptophan into serotonin. At 15,000 IU daily, along with vitamin K2, my mood and sleep improved, significantly, for two weeks but by the second week I began to develop constipation which didn't resolve until a few days after I stopped D. Puchacz E, Stumpf W E, Stachowiak E K, Stachowiak M K. Vitamin D increases expression of the tyrosine hydroxylase gene in adrenal medullary cells. Vitamin D may also improve oxytocin production. Mechanism proposed that links decreased levels of vitamin D and serotonin in autism patients. Mol Brain Res 1996; 36: 193-196. Deficiency of this vitamin is widespread in the population. Vitamin D also fulfills very important functions in the synthesis of serotonin, this vitamin regulates the synthesis of enzymes that convert the amino acid tryptophan into serotonin. • Vitamin D regulates TPH2 (in brain) and TPH1 (in gut), in serotonin synthesis pathways. Per vitamin D lowering gut serotonin; Late last year, I ramped up my intake of vitamin D to see if it would reverse the depression I was experiencing and lower gut inflammation.

Link Between Vitamin D, Serotonin Synthesis and Autism Discovered by Colleen Fleiss on August 25, 2019 at 2:06 PM Child Health News
The study reminds me of another one, which found that vitamin D reduced peripheral serotonin synthesis.

Vitamin D . by Children's Hospital & Research Center Oakland • Vitamin D may be an epigenetic factor in regulation and function of oxytocin. Although both are individually essential for the body but one commences it action when the other ceases to act.

What's more, your bones need it to stay healthy and strong, your cells need it to grow, your nerves need it to carry messages between the brain and other body parts, and your immune system needs it to fend off viruses and bacteria. Your body needs this key vitamin to absorb calcium. Supplementation with vitamin D and tryptophan is a practical and affordable solution to help prevent autism and possibly ameliorate some symptoms of the disorder.—Patrick, R. P., Ames, B. N. Vitamin D hormone regulates serotonin synthesis. Vitamin D Lowers Gut Serotonin But Increases Brain Serotonin Given that dopamine and dopamine agonists reduce activity of tryptophan hydroxylase and thus serotonin synthesis, the study below provides one possible explanation of how vitamin D lowers serotonin. Abstract: Serotonin and vitamin D have been proposed to play a role in autism; however, no causal mechanism has been established. Rhonda P. Patrick And Bruce N. Ames. Part 1: relevance for … Cells in culture were challenged with 1, 10, and 100 nM 1,25D, and mRNA was isolated, reverse transcribed to cDNA and probed for SERT and MAO … Vitamin D and its receptors are in areas of brain that are in relation with mood and behavior. In conclusion, the levels of serotonin in winter might in fact be determined by the duration of light exposure the previous summer.

Administer L-Tryptophan with Vitamin D – as vitamin D will enhance serotonin synthesis in the brain and limit its production in the gut. To determine if vitamin D affects the major route of serotonin reuptake and degradation, the influence of 1,25D on the expression of SERT and MAO-A was assessed by quantitative real-time PCR in differentiated serotonergic rat raphe RN46A-B14 cells. Avoid serotonin reuptake inhibitors (SSRIs) – they have been used in autism but with mixed results, likely because their effect on serotonin is unclear. Vitamin D hormone regulates serotonin synthesis. Research suggests vitamin D could affect brain function. Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar, schizophrenia, and impulsive behavior.

In this synthesis, L-tryptophan first gets metabolized to 5-hydroxytryptophan from which 5-hydroxytryptamine, also known as serotonin, is made.
New study finds vitamin D helps to regulate three genes involved in autism. Inadequate levels of vitamin D (∼70% of the population) and omega-3 fatty acids are common, suggesting that brain serotonin synthesis is not optimal.

The functions of Vitamin D and melatonin are contrary to each other. Melatonin is synthesized endogenously by the pinealocytes of the pineal gland. This nutrient is present in certain foods, but human beings tend to derive it in maximum proportions from the sunlight. Part 1: … References 1. Vitamin D is important to the body in many ways.

The essential amino acid L-tryptophan is a precursor in the synthesis of melatonin. Vitamin D, the vitamin which is formed only by solar radiation, could be the most important "missing" vitamin for your mood. We propose mechanisms by which EPA increases serotonin release from presynaptic neurons by reducing E2 series prostaglandins and DHA influences serotonin receptor action by increasing cell membrane fluidity in postsynaptic neurons. New research indicates causal link between vitamin D, serotonin synthesis and autism.

Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.It has a popular image as a contributor to feelings of well-being and happiness, though its actual biological function is complex and multifaceted, modulating cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.